Fig. 1 · Structure
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Br-PBTC
nAChRs Allosteric Modulator
Br-PBTC is a selective positive allosteric modulator of nicotinic acetylcholine receptors (nAChRs), specifically targeting the α2β2, α2β4, α4β2, α4β4, (α4β2)2α4, and (α4β2)2β2 subtypes with effective concentration (EC50) values ranging from 0.1 to 0.6 μM. By acting on the c-terminal region of the α subunit, Br-PBTC enhances receptor activity, making it a valuable tool for studying nAChR-mediated signaling pathways and their implications in neuropharmacology and related fields.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1839519-57-1 |
| Applications | nAChRs Allosteric Modulator |
| Formula | C14H15BrN2OS |
| Molecular Weight | 339.25 |
| SMILES | O=C(C1=CC2=CC=CC(Br)=C2S1)N[C@H]3CNCCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.