Fig. 1 · Structure
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Bradanicline hydrochloride
α7 nAChR Agonist
Bradanicline hydrochloride is a selective agonist for the α7 nicotinic acetylcholine receptor (nAChR), exhibiting an EC50 of 17 nM and a Ki of 1.4 nM for the human α7 nAChR. This compound demonstrates significant biological activity that supports research into cognitive disorders and schizophrenia. Its targeted mechanism makes it a valuable tool for studying therapeutic approaches in neuropsychiatric conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1111941-90-2 |
| Applications | α7 nAChR Agonist |
| Formula | C22H24ClN3O2 |
| Molecular Weight | 397.90 |
| Synonyms | TC-5619 hydrochloride |
| SMILES | O=C(N[C@H]1[C@@H](N2CCC1CC2)CC3=CC=CN=C3)C4=CC5=CC=CC=C5O4.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.