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Bradanicline tosylate

α7 nAChR Agonist

Bradanicline tosylate is a selective agonist for the α7 nicotinic acetylcholine receptor (nAChR) with significant oral bioavailability and moderate blood-brain barrier penetration. It demonstrates high affinity and subtype specificity for human α7 nAChR, exerting antitussive effects through prolonged receptor activation. Bradanicline tosylate effectively inhibits cough responses induced by citric acid, bradykinin, and inhaled nicotine in a dose-dependent manner. This compound is well tolerated in preclinical studies, making it a valuable tool in research focused on chronic refractory cough and related therapeutic areas.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	1111942-11-0
Applications	α7 nAChR Agonist
Formula	C₂₉H₃₁N₃O₅S
Molecular Weight	533.64
Synonyms	TC-5619 tosylate
SMILES	O=S(O)(C1=CC=C(C=C1)C)=O.O=C(C2=CC3=CC=CC=C3O2)N[C@H](C4CCN5CC4)[C@@H]5CC6=CN=CC=C6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.