Fig. 1 · Structure
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BRD-7880
AURKB/C Inhibitor
BRD-7880 is a potent inhibitor of Aurora Kinase B (AURKB) and Aurora Kinase C (AURKC), demonstrating IC50 values of 7 nM and 12 nM, respectively. This compound exhibits significant selective inhibition, making it a valuable tool in cancer research, particularly in studying the role of these kinases in cell division and tumorigenesis. BRD-7880 may be used to investigate the therapeutic potential of targeting the AURKB/C pathway in various malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1456542-69-0 |
| Applications | AURKB/C Inhibitor |
| Formula | C32H38N4O7 |
| Molecular Weight | 590.67 |
| SMILES | O=C1C2=CC(NC(NC3=CC=C(C=C3)OC)=O)=CC=C2O[C@H]([C@H](CN1[C@@H](C)CO)C)CN(C)CC4=CC=C(OCO5)C5=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.