Fig. 1 · Structure
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BRD-K98645985
BAF Inhibitor
BRD-K98645985 is a selective inhibitor of BAF (mammalian SWI/SNF) complexes, exhibiting an EC50 of approximately 2.37 μM. This compound specifically targets ARID1A-containing BAF complexes, disrupting nucleosomal positioning and effectively reversing HIV-1 latency. Its mechanism operates without inducing T cell activation or exhibiting cytotoxic effects, making it a valuable tool for studies in transcriptional regulation and HIV research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1357647-78-9 |
| Applications | BAF Inhibitor |
| Formula | C33H43N5O4 |
| Molecular Weight | 573.73 |
| SMILES | O=C(NC1=CC=C(OC[C@H](C)N(CC2=CC=C(C3=NC=CC=C3)C=C2)C[C@H](C)[C@@H](OC)CN(C)C4=O)C4=C1)NC(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.