Fig. 1 · Structure
Documents & Downloads
BRD0539
SpCas9 Inhibitor
BRD0539 is an inhibitor of Streptococcus pyogenes Cas9 (SpCas9), exhibiting an IC50 of 22 μM in vitro during DNA cleavage assays. This compound serves as a valuable tool for investigating the regulation of CRISPR-Cas9 genome editing activities. Its selective inhibition of SpCas9 enhances studies related to gene expression modulation and potential therapeutic applications in genetic engineering.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1403838-79-8 |
| Applications | SpCas9 Inhibitor |
| Formula | C25H25FN2O3S |
| Molecular Weight | 452.54 |
| SMILES | OC[C@@H]1NC2=C(C=C(C3=CC=CC=C3F)C=C2)[C@@]4([H])[C@]1([H])CCN4S(=O)(C5=CC=C(C)C=C5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.