Fig. 1 · Structure
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BRD4-IN-2
Epigenetic Reader Domain
BRD4-IN-2 is a selective inhibitor of the bromodomain-containing protein BRD4, demonstrating an IC50 value of 9.9 nM. This compound plays a significant role in epigenetic regulation by disrupting protein-protein interactions mediated by BRD4. It is primarily utilized in research focused on cancer biology, inflammation, and neurological disorders, facilitating the investigation of epigenetic modulation and potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2679925-55-2 |
| Applications | Epigenetic Reader Domain |
| Formula | C43H48N8O11 |
| Molecular Weight | 852.89 |
| SMILES | CNC(N1N=C(C2=C(C[C@@H]1C)C=C(C(OC)=C2)OC)C3=CC=C(C=C3)N4CCN(CC4)C(COCCOCC(NC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.