Fig. 1 · Structure
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BRD4 Inhibitor-37
Epigenetic Reader Domain
BRD4 Inhibitor-37 is a selective antagonist of the Epigenetic Reader Domain BRD4, demonstrating significant anticancer activity. With an IC50 ranging from 0.05-0.1 μM in binding assays and a GI50 of 0.1-0.3 μM in cellular models, this compound effectively impedes the c-Myc signaling pathway, a critical downstream target of BRD4. Its selectivity across multiple bromodomain proteins positions BRD4 Inhibitor-37 as an important tool for investigating BET protein functions in cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1095051-79-8 |
| Applications | Epigenetic Reader Domain |
| Formula | C9H6FNOS |
| Molecular Weight | 195.21 |
| SMILES | O=C1SC=C(C2=C(F)C=CC=C2)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.