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Breceptin

B1/B2R Antagonist

Breceptin is an antagonist of the bradykinin B1 and B2 receptors (B1/B2R). This compound exhibits an irreversible antagonistic effect on the B2 receptor, effectively inhibiting bradykinin-induced vasodilation as demonstrated in rabbit carotid vein contraction assays. Additionally, Breceptin displays partial agonist activity in HEK 293 cells with high B2R expression, facilitating ERK1/2 phosphorylation and calcium ion mobilization while promoting arachidonic acid release and receptor internalization. Due to its unique properties, Breceptin serves as a valuable tool for research into breast cancer and non-small cell lung cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	215713-39-6
Applications	B1/B2R Antagonist
Formula	C₁₃₆H₂₀₀N₃₈O₂₈
Molecular Weight	2815.28
Synonyms	B 9870
SMILES	O=C(NCC(N[C@H](C(N[C@H](C(N[C@@H](C(N1[C@@]2([C@]([H])(C[C@H]1C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)CCCC2)[H])=O)C3CC4=C(C3)C=CC=C4)=O)CO)=O)C5CC6=C(C5)C=CC=C6)=O)[C@H]7N(C([C@H]8N(C([C@@H](NC([C@H](NC(CCCCCCC(N[C@@H](C(N[C@H](C(N9[C@H](C(N%10[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](C(N%11[C@@]%12([C@]([H])(C[C@H]%11C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)CCCC%12)[H])=O)C%13CC%14=C(C%13)C=CC=C%14)=O)CO)=O)C%15CC%16=C(C%15)C=CC=C%16)=O)=O)C[C@H](C%10)O)=O)CCC9)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC8)=O)C[C@@H](C7)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.