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Brefeldin A 4-O-nicotinate

Arf1/BMX Inhibitor

Brefeldin A 4-O-nicotinate is a dual inhibitor of Arf1 and BMX proteins, demonstrating significant anti-cancer properties. It has an IC50 value of 0.22 μM for the proliferation of T24 bladder cancer cells and effectively inhibits cell migration and colony formation in a dose-dependent manner. Additionally, it induces G1 phase cell cycle arrest and triggers apoptosis. By targeting BMX, Brefeldin A 4-O-nicotinate disrupts the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, while its inhibition of Arf1 helps eliminate cancer stem cells and enhances anti-tumor immunity. This compound is valuable for research applications focused on bladder cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3035018-34-6
Applications	Arf1/BMX Inhibitor
Formula	C₂₂H₂₇NO₅
Molecular Weight	385.45
Synonyms	CHNQD-01228
SMILES	O=C1O[C@@H](C)CCC/C=C/[C@@]2([H])[C@](C[C@@H](O)C2)([H])[C@H](OC(C3=CN=CC=C3)=O)/C=C/1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.