Fig. 1 · Structure
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Brexpiprazole hydrochloride
Antipsychotic Agent
Brexpiprazole hydrochloride is an atypical antipsychotic agent that functions as a partial agonist at the human 5-HT1A and dopamine D2L receptors, exhibiting Kis of 0.12 nM and 0.3 nM, respectively. Additionally, it serves as a potent antagonist of the 5-HT2A receptor with a Ki of 0.47 nM. Brexpiprazole hydrochloride demonstrates significant antagonist activity at human noradrenergic α1B and α2C receptors, with Kis of 0.17 nM and 0.59 nM, respectively. This compound is primarily utilized in research exploring the treatment of psychiatric disorders, including schizophrenia and major depressive disorder.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 913612-38-1 |
| Applications | Antipsychotic Agent |
| Formula | C25H28ClN3O2S |
| Molecular Weight | 433.6 |
| Synonyms | OPC-34712 hydrochloride |
| SMILES | O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5)C5=CC=C4)CC3)=C2)C=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.