Brigatinib (AP26113)

Catalog No.: A13450

ALK Inhibitor

Brigatinib (AP26113)

Brigatinib (AP26113) Chemical Structure

CAS NO. 1197953-54-0

Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.

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5 mg

Regular Price: $45.00

Special Price $36.00

10 mg

Regular Price: $65.00

Special Price $52.00

25 mg

Regular Price: $120.00

Special Price $96.00

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Biological Activity

Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
In vitro DMSO Warmed: 1 mg/mL (1.71 mM)
Water Insoluble
Ethanol Warmed: 39 mg/mL (66.76 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.12 mL 85.6 mL 171.21 mL
0.5 mM 3.42 mL 17.12 mL 34.24 mL
1 mM 1.71 mL 8.56 mL 17.12 mL
5 mM 0.34 mL 1.71 mL 3.42 mL

*The above data is based on the productmolecular weight 584.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13450
Actions Inhibitor
CAS No. 1197953-54-0
Formula C29H39ClN7O2P
M. Wt 584.09
Purity >98%
Synonyms AP-26113, AP 26113, AP26113
SMILES CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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