Fig. 1 · Structure
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Brigimadlin
MDM-2 Inhibitor
Brigimadlin is an orally active inhibitor of the E3 ubiquitin-protein ligase MDM-2, which plays a crucial role in the regulation of the tumor suppressor protein p53. By preventing MDM-2 from mediating the degradation of p53, Brigimadlin enhances p53 activity, promoting apoptosis in cancer cells. This compound is primarily utilized in antineoplastic research to explore therapeutic strategies targeting p53 signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2095116-40-6 |
| Applications | MDM-2 Inhibitor |
| Formula | C31H25Cl2FN4O3 |
| Molecular Weight | 591.46 |
| Synonyms | BI 907828 |
| SMILES | OC(C1=C(C)C2=NN([C@@]([C@]3([H])C4)([H])[C@H](C5=C(C(Cl)=CC=C5)F)[C@@]6(C7=CC=C(Cl)C=C7NC6=O)N3CC8CC8)C4=C2C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.