Fig. 1 · Structure
Documents & Downloads
BRK inhibitor P21d hydrochloride
BRK Inhibitor
BRK inhibitor P21d hydrochloride is a selective inhibitor of breast tumor kinase (BRK/PTK6), exhibiting an IC50 of 30 nM. This compound effectively inhibits p-SAM68 with an IC50 of 52 nM, making it a valuable tool for studying BRK signaling pathways. It is particularly useful in evaluating the in vivo efficacy of BRK inhibitors in xenograft breast tumor models, facilitating research into targeted therapies for breast cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2250025-98-8 |
| Applications | BRK Inhibitor |
| Formula | C23H23ClFN7O2 |
| Molecular Weight | 483.93 |
| SMILES | O=C(C1=CC=C(NC2=NC(C3CC3)=CN4C2=NC=C4C5=CNN=C5)C(F)=C1)N6CCOCC6.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.