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BRL 34778

Dopamine D2 Receptor Antagonist

BRL 34778 is a highly selective dopamine D2 receptor antagonist with a Ki value of 2.14 nM, demonstrating significant potency in receptor inhibition. It exhibits antipsychotic properties while minimizing extrapyramidal side effects and sedation. This compound is valuable for investigating neurological disorders, particularly schizophrenia, and contributes to research focused on the modulation of dopaminergic pathways in the brain.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	86580-77-0
Applications	Dopamine D2 Receptor Antagonist
Formula	C₂₃H₂₇ClFN₃O₂
Molecular Weight	431.93
SMILES	O=C(C1=C(C=C(N)C(Cl)=C1)OC)N[C@@H](C[C@@H]2CCC3)C[C@@H]3N2CC4=CC=C(F)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.