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BRM/BRG1 ATP degrader-1

BRG1/BRM Degrader

BRM/BRG1 ATP degrader-1 is a selective degrader targeting BRG1 and BRM, exhibiting IC50 values of 0.01-0.1 μM for BRM degradation and greater than 0.1 μM for BRG1. This compound facilitates the investigation of the functional roles of these proteins in various cellular processes, making it a valuable tool for cancer research. Its mechanism of action provides insights into underlying pathways and mechanisms that may contribute to tumorigenesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2901804-30-4
Applications	BRG1/BRM Degrader
Formula	C₂₉H₃₄N₈O
Molecular Weight	510.65
SMILES	OC1=CC=CC=C1C=2N=NC(N)=C(C2)N3CC4N(C=5C=CN=C(C#CCCN6CCNCC6)C5)C(C3)CC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.