Fig. 1 · Structure
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BRM/BRG1 ATP Inhibitor-3
BRG1/BRM Inhibitor
BRM/BRG1 ATP Inhibitor-3 selectively targets the BRG1 and BRM ATPases, exhibiting inhibitory activity with IC50 values of 10.4 nM and 19.3 nM, respectively. This compound is valuable for investigating the roles of the BAF complex in various cancers and related disorders. Its effective inhibition of chromatin remodeling can provide insights into therapeutic strategies for targeting these pathways in oncology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2368901-31-7 |
| Applications | BRG1/BRM Inhibitor |
| Formula | C26H25N5O2S2 |
| Molecular Weight | 503.64 |
| SMILES | O=C(C1=CC=C(C=C1)N)N[C@@H](CCSC)C(NC2=NC(C3=CC(C4=CC=NC=C4)=CC=C3)=CS2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.