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Brodalumab

Brodalumab (AMG 827) is a humanized IgG2 monoclonal antibody targeting the interleukin-17 receptor. This antibody is utilized in research focused on understanding and treating moderate-to-severe plaque psoriasis and rheumatoid arthritis. Brodalumab's mechanism involves blocking the activity of interleukin-17 (IL-17), a cytokine that plays a critical role in mediating inflammatory and immune responses.

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Biological Activity

Target & Activity

IL-17R

Product Details

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 1174395-19-7
Molecular Weight 144060
Synonyms AMG 827; KHK4827

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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