Fig. 1 · Structure
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Bromhexine hydrochloride
TMPRSS2 Protease Inhibitor
Bromhexine hydrochloride is a selective inhibitor of the TMPRSS2 protease, exhibiting an IC50 of 0.75 μM. This compound has demonstrated efficacy in preventing and managing SARS-CoV-2 infections. Additionally, bromhexine hydrochloride acts as an autophagy agonist and serves as a mucolytic cough suppressant, making it suitable for research related to various respiratory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 611-75-6 |
| Applications | TMPRSS2 Protease Inhibitor |
| Formula | C14H21Br2ClN2 |
| Molecular Weight | 412.59 |
| SMILES | CN(C1CCCCC1)CC2=CC(Br)=CC(Br)=C2N.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.