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Brontictuzumab

Brontictuzumab (OMP 52M51) is a monoclonal antibody designed to target and inhibit the Notch1 signaling pathway. This antibody specifically binds to the negative regulatory region of Notch1, a critical component in cell differentiation, proliferation, and apoptotic processes. By inhibiting this pathway, Brontictuzumab effectively impedes tumor cell proliferation, making it a valuable tool in the study of hematological malignancies such as leukemia and lymphoma. Its selective binding affinity and inhibitory action on Notch1 provide a focused approach for researchers investigating the pathological roles of Notch1 signaling in cancer.

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Product Details

Manufacturer Adooq Bioscience
CAS Number 1447814-75-6
Molecular Weight 145500
Synonyms OMP 52M51; Anti-Human NOTCH1 Recombinant Antibody

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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