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Fig. 1 · Structure
Cat. No.
A19811
CAS No.
41451-75-6
Formula
C28H36O11
Mol. Weight
548.58

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Bruceantin

Cat. No. A19811 CAS 41451-75-6
Bruceantin(NSC165563) is first isolated from Brucea antidysenterica.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
BV-173 IC50 < 15 ng/mL Cytotoxicity against human BV173 cells by trypan blue exclusion method [PMID: 14987068]
Daudi IC50 < 15 ng/mL Cytotoxicity against human Daudi cells by trypan blue exclusion method [PMID: 14987068]
HeLa IC50 0.051 μM Inhibition of protein synthesis in human HeLa cells assessed as [35S]methionine incorporation into protein treated for 45 mins before [35S]methionine addition by Whatman paper analysis [PMID: 19199792]
HL-60 EC50 0.02 μM Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay [PMID: 11754601]
HL-60 IC50 0.04 μM Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay [PMID: 11754601]
HL-60 IC50 0.04 μM Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter [PMID: 11754601]
HL-60 IC50 12.2 nM Induction of apoptosis in human HL60 cells after 24 hrs by DAPI staining [PMID: 14987068]
HL-60 IC50 20 ng/mL Cytotoxicity against human HL60 cells by trypan blue exclusion method [PMID: 14987068]
Kasumi 1 IC50 20 ng/mL Cytotoxicity against human Kasumi-1 cells by trypan blue exclusion method [PMID: 14987068]
LNCaP ED50 11 nM Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodamine B assay [PMID: 19026551]
Lu1 ED50 12 nM Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay [PMID: 19026551]
MCF7 ED50 0.27 nM Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay in presence of 43 uM (-)-hydnocarpin [PMID: 19026551]
MCF7 ED50 2 nM Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay [PMID: 19026551]
NB-4 IC50 < 15 ng/mL Cytotoxicity against human NB4 cells by trypan blue exclusion method [PMID: 14987068]
NCI-H929 IC50 115 nM Induction of apoptosis in human NCI-H929 cells after 24 hrs by DAPI staining [PMID: 14987068]
REH IC50 20 ng/mL Cytotoxicity against human REH cells by trypan blue exclusion method [PMID: 14987068]
RPMI-8226 IC50 12.8 nM Induction of apoptosis in human RPMI8226 cells after 24 hrs by DAPI staining [PMID: 14987068]
RS4-11 IC50 < 15 ng/mL Cytotoxicity against human RS4:11 cells by trypan blue exclusion method [PMID: 14987068]
SU-DHL-6 IC50 < 15 ng/mL Cytotoxicity against human DHL6 cells by trypan blue exclusion method [PMID: 14987068]
U-266 IC50 49 nM Induction of apoptosis in human U266 cells after 24 hrs by DAPI staining [PMID: 14987068]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 41451-75-6
Formula C28H36O11
Molecular Weight 548.58
Synonyms (-)-Bruceantin; NCI165563; NSC165563
SMILES
O=C([C@@]1([C@H]([C@H](O)[C@]2([H])[C@]3(C4)C)O)[C@@]([C@H](C5=O)OC(/C=C(C)/C(C)C)=O)([H])[C@@]2([C@@](O5)([H])C[C@@]3([H])C(C)=C(O)C4=O)CO1)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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