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BSF-466895

Catalog No.: A84782
Tie2 Inhibitor
BSF-466895 is a potent Tie2 inhibitor with an IC50 value of 5 nM, demonstrating significant inhibition of Tie1 as well. This compound is valuable for research applications focused on vascular biology and angiogenesis, as well as exploring the therapeutic potential in disorders related to angiogenic dysregulation. BSF-466895 serves as a useful tool for elucidating the role of the Tie2 signaling pathway in various biological contexts.
BSF-466895 262442-90-0 Tie2 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBSF-466895 is a potent Tie2 inhibitor with an IC50 value of 5 nM, demonstrating significant inhibition of Tie1 as well. This compound is valuable for research applications focused on vascular biology and angiogenesis, as well as exploring the therapeutic potential in disorders related to angiogenic dysregulation. BSF-466895 serves as a useful tool for elucidating the role of the Tie2 signaling pathway in various biological contexts.
Product Information
Catalog NumA84782
FormulaC29H32Cl2FN7O2S
Molecular Weight632.58
CAS Number262442-90-0
SMILESO=S(C1=CC=CC(Cl)=C1Cl)(NC2=CC=C(C3=CN([C@H]4CC[C@H](N5CCN(C)CC5)CC4)C6=NC=NC(N)=C63)C=C2F)=O
SynonymsA-422885.66
Useful Calculator

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Protein Tyrosine Kinases > Tie-2