Fig. 1 · Structure
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BU224 hydrochloride
I2 Receptor Ligand
BU224 hydrochloride is a selective, high-affinity imidazoline I2 receptor ligand with a Ki of 2.1 nM, functioning primarily as an I2 receptor antagonist. It exhibits neuroprotective properties, demonstrating anti-inflammatory and anti-apoptotic effects. Research indicates that BU224 hydrochloride enhances memory in 5XFAD mice by promoting dendritic spine enlargement and mitigating Aβ-induced alterations in NMDARs. This compound is valuable for exploring potential therapeutic strategies in Alzheimer's disease research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 205437-64-5 |
| Applications | I2 Receptor Ligand |
| Formula | C12H12ClN3 |
| Molecular Weight | 233.70 |
| SMILES | C1(C2=NCCN2)=NC3=CC=CC=C3C=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.