Fig. 1 · Structure
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Buloxibutid
AT2 receptor agonist
Buloxibutid is a selective angiotensin II AT2 receptor agonist, demonstrating a potent Ki value of 0.4 nM for the AT2 receptor while showing minimal affinity for the AT1 receptor (>10 μM). This compound is valuable in research applications focusing on cardiovascular function and neuroprotection, as it modulates AT2 receptor signaling pathways. Buloxibutid may facilitate studies exploring its therapeutic potential in various disease models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 477775-14-7 |
| Applications | AT2 receptor agonist |
| Formula | C23H29N3O4S2 |
| Molecular Weight | 475.62 |
| Synonyms | AT2 receptor agonist C21 |
| SMILES | O=C(OCCCC)NS(=O)(C1=C(C2=CC=C(CN3C=CN=C3)C=C2)C=C(CC(C)C)S1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.