Fig. 1 · Structure
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Bumetanide-d5
NKCC1 Inhibitor
Bumetanide-d5 is a deuterium-labeled derivative of Bumetanide, a selective inhibitor of the Na+-K+-Cl- cotransporter 1 (NKCC1). It exhibits weak inhibitory activity on NKCC2, with reported IC50 values of 0.68 μM for hNKCC1A and 4.0 μM for hNKCC2A. This reagent is valuable for studying electrolyte transport and the physiological roles of NKCC transporters in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1216739-35-3 |
| Applications | NKCC1 Inhibitor |
| Formula | C17H15D5N2O5S |
| Molecular Weight | 369.45 |
| SMILES | O=C(O)C1=CC(NCCCC)=C(OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(S(=O)(N)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.