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Butyrolactone Ia

NO Inhibitor

Butyrolactone Ia is a selective inhibitor of nitric oxide (NO) production, exhibiting an IC50 of 18 μM. This compound effectively inhibits lipopolysaccharide (LPS)-induced mRNA expression of inducible nitric oxide synthase (iNOS) and the pro-inflammatory cytokine interleukin-1 beta (IL-1β). Additionally, Butyrolactone Ia has been shown to modulate autophagy in HeLa cells and possesses immunosuppressive properties, making it a valuable tool for research into inflammation and immune response regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	942986-92-7
Applications	NO Inhibitor
Formula	C₂₃H₂₂O₇
Molecular Weight	410.42
SMILES	OC([C@]1(C(C2=CC=C(C=C2)O)=C(C(O1)=O)O)CC3=CC(C/C=C(C)\C)=C(C=C3)O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.