Fig. 1 · Structure
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BV02
14-3-3 PPI Inhibitor
BV02 is a potent inhibitor of 14-3-3 protein-protein interactions. It induces apoptosis and autophagy through the cleavage of PARP and activation of caspase-3, while also enhancing Akt activation. BV02 demonstrates significant antibacterial activity against Brucella melitensis and shows promise in studying epilepsy and colitis-related mechanisms. Its diverse biological activity makes it a valuable tool in various research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 292870-53-2 |
| Applications | 14-3-3 PPI Inhibitor |
| Formula | C20H15N3O5 |
| Molecular Weight | 377.36 |
| SMILES | O=C(C1=CC2=C(C(N(C3=C(C)N(C)N(C4=CC=CC=C4)C3=O)C2=O)=O)C=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.