Fig. 1 · Structure
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BX-320
PDK1 Inhibitor
BX-320 is a selective, ATP-competitive inhibitor of 3-phosphoinositide-dependent protein kinase-1 (PDK1) with an IC50 of 30 nM, demonstrating potent inhibition in direct kinase assays. This compound not only inhibits PDK1 activity but also induces apoptosis in various cancer cell types, showcasing its potential as an anticancer agent. BX-320 is suitable for research applications focused on cancer biology and signal transduction pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 702676-93-5 |
| Applications | PDK1 Inhibitor |
| Formula | C23H31BrN8O3 |
| Molecular Weight | 547.45 |
| SMILES | O=C(C(C)(C)C(N)=O)NCCCNC1=C(Br)C=NC(NC2=CC=CC(NC(N3CCCC3)=O)=C2)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.