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Biological Activity
BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.7 mL | 123.49 mL | 246.97 mL |
| 0.5 mM | 4.94 mL | 24.7 mL | 49.39 mL |
| 1 mM | 2.47 mL | 12.35 mL | 24.7 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
*The above data is based on the productmolecular weight 404.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18972 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2247236-59-3 |
| Formula | C22H21ClN6 |
| M. Wt | 404.9 |
| Purity | >98% |
| Synonyms | BY-27, BY 27 |
| SMILES | CN1N=CC(C2=CC=C(N3C(CC[[email protected]]4NC5=CC=C(Cl)C=C5)=NN=C3C)C4=C2)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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