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BYBC-1

G4-RNA-Targeting Ligand

BYBC-1 is a selective G4-RNA-targeting ligand that demonstrates high affinity for KRAS and NRAS G4-RNAs, with a Kd range of 0.05-0.28 μM. This compound stabilizes G4-RNA structures in KRAS and NRAS mRNA, leading to the inhibition of the PI3K/AKT and MAPK/ERK signaling pathways. BYBC-1 activates the DNA damage response, suppresses energy metabolism, and induces S-phase arrest and apoptosis in malignant cells. Its preferential toxicity towards cancer cells over non-malignant fibroblasts, along with its efficacy in reducing the growth of HCT-116 xenograft tumors, makes BYBC-1 a valuable tool for colorectal cancer research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2563902-57-6
Applications	G4-RNA-Targeting Ligand
Formula	C₂₅H₂₃BrN₂O₂S
Molecular Weight	495.43
SMILES	CC1(C(/C=C2N(C3=C(S/2)C=CC=C3)C)=[N+](C4=CC=C5C(C=CC=C5)=C41)CC(O)=O)C.[Br-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.