Fig. 1 · Structure
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C2 Adamantanyl galactosylceramide (d18:1/2:0)
GlcCer Inhibitor
C2 Adamantanyl galactosylceramide (d18:1/2:0) is a bioactive sphingolipid that primarily targets glucocerebrosidase. This compound effectively stimulates glucocerebrosidase activity in vitro and demonstrates inhibition of microsomal LacCer and Gb3 synthase, while also suppressing cell sulfatide synthesis. C2 Adamantanyl galactosylceramide reduces glucosylceramide (GlcCer) levels in both normal and lysosomal storage disease (LSD) cells, and it serves as a substrate for A4GALT, achieving a reduction in Gb3 levels in Fabry disease cells at an IC50 concentration of 40 μM. Its utility extends to the investigation of sphingolipid metabolism and potential therapeutic strategies for lysosomal storage disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 574738-16-2 |
| Applications | GlcCer Inhibitor |
| Formula | C36H63NO8 |
| Molecular Weight | 637.89 |
| Synonyms | AdaGalCer(d18:1/2:0); Admantanyl galactosylceramide (d18:1/2:0); Admantanyl galCer(d18:1/2:0) |
| SMILES | OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CC23CC4CC(CC(C4)C3)C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.