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C5aR1 antagonist 1

C5aR1 antagonist

C5aR1 antagonist 1 is a selective antagonist of the complement component 5a receptor 1 (C5aR1) with notable oral bioavailability. It exhibits potent activity in both DISCO and migration assays, demonstrating IC50 values of 38 nM and 17 nM, respectively. This compound is suitable for investigating the roles of C5aR1 in acute and chronic inflammatory diseases, facilitating research into potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2365325-67-1
Applications	C5aR1 antagonist
Formula	C₂₈H₂₇F₄N₃O
Molecular Weight	497.53
SMILES	O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(CN1C4CCN(CC4)C5=C(C)C=CC=C5F)C=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.