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C5aR1 antagonist 2

C5aR1 Antagonist

C5aR1 antagonist 2 is an orally active antagonist targeting the C5a receptor 1 (C5aR1). It effectively inhibits C5a-induced neutrophil recruitment, demonstrated by IC50 values of 21 nM in DISCO assays and 3 nM in migration assays. This compound is suitable for research into acute and chronic inflammatory diseases, providing a valuable tool for understanding the role of C5aR1 in inflammatory processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2365161-92-6
Applications	C5aR1 Antagonist
Formula	C₂₉H₃₀F₃N₃O₂
Molecular Weight	509.56
SMILES	O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(N1C4CCN(CC4)C5=C(C)C=CC=C5C)C=CC=C3OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.