Fig. 1 · Structure
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CA IX-IN-2
CA Inhibitor
CA IX-IN-2 is a potent inhibitor of carbonic anhydrase, specifically targeting CA IX, CA XII, and CA II with IC50 values of 5.6, 7.4, and 430 nM, respectively. This compound demonstrates significant biological activity by inhibiting the proliferation of various cancer cell lines, including HCT-116, SW480, MDA-MB-231, and MCF-7, with IC50 values ranging from 14.63 to 29.33 μM. CA IX-IN-2 disrupts the cell cycle by arresting it at the G1/S phase, induces apoptosis, and affects mitochondrial functions, including mitochondrial membrane potential and ROS levels. Additionally, it shows promise in reducing cell migration and exhibits antitumor efficacy in preclinical mouse models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3009842-92-3 |
| Applications | CA Inhibitor |
| Formula | C30H36N6O5S |
| Molecular Weight | 592.71 |
| SMILES | O=C(C1=CC=C(C2=CC=CC(C3=O)=C12)N4CCN(CC4)CC(NC5=CC=C(C=C5)S(N)(=O)=O)=O)N3CCN(CC)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.