Fig. 1 · Structure
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CA77.1
CMA Activator
CA77.1 is a potent chaperone-mediated autophagy (CMA) activator that effectively penetrates the brain and demonstrates favorable pharmacokinetics. This compound enhances the expression of the lysosomal receptor LAMP2A, facilitating autophagic processes within lysosomes. Research indicates that CA77.1 improves behavioral outcomes and neuropathological features in the PS19 mouse model, making it a valuable reagent for studies focused on Alzheimer’s disease and related neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2412270-22-3 |
| Applications | CMA Activator |
| Formula | C16H12ClN3O |
| Molecular Weight | 297.74 |
| SMILES | CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.