Fig. 1 · Structure
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Cadefrecitinib
Tyk2 Inhibitor
Cadefrecitinib is a reversible, ATP-competitive inhibitor of TYK2, exhibiting an IC50 of 2.3 nM. This compound effectively inhibits the IFNα/pSTAT1 signaling pathway, demonstrating additional IC50 values of 70 nM in human peripheral blood mononuclear cells and 623 nM in whole blood assays. Cadefrecitinib is a valuable tool for researching inflammatory and autoimmune diseases, contributing to the understanding of mechanistic pathways involved in these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2308520-97-8 |
| Applications | Tyk2 Inhibitor |
| Formula | C22H21N9O2 |
| Molecular Weight | 443.46 |
| Synonyms | GLPG3667 |
| SMILES | N#CC1=NC=C(C(C)=C1)OC2=CC(NC3=NN=C(N4CCOCC4)C=C3)=C(N=CN5C)C5=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.