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CAII/VII-IN-1

hCA II/VII Inhibitor

CAII/VII-IN-1 is a potent inhibitor of human carbonic anhydrases II and VII, with inhibition constants of 12.3 nM and 22.6 nM, respectively, and minimal activity against human carbonic anhydrase I. This compound exhibits significant neuroprotective effects in vivo, demonstrated through its efficacy in the Pilocarpine-induced seizure model. CAII/VII-IN-1 positively influences the expression of KCC2 and inhibits mTOR signaling pathways, contributing to its neuroprotective profile without notable neurotoxicity or adverse effects on liver and kidney function. It is a valuable tool for research focused on epilepsy and neuroprotection.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3085155-69-4
Applications	hCA II/VII Inhibitor
Formula	C₂₇H₂₃ClN₈O₅S₂
Molecular Weight	639.11
SMILES	ClC1=CC=C(C=C1)C2=NN(C=C2/C=N/NC(C3=C(N(N=N3)C4=CC=C(C=C4)S(N)(=O)=O)C)=O)C5=CC=C(C=C5)S(C)(=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.