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CAIX/CAXII-IN-1

CAIX/CAXII Inhibitor

CAIX/CAXII-IN-1 is a potent inhibitor of carbonic anhydrase IX (CAIX) and carbonic anhydrase XII (CAXII), demonstrating Ki values of 29.1 nM and 8.8 nM, respectively. This compound exhibits significant cytotoxicity against various cancer cell lines, including HepG-2, HCT-116, and MCF-7, with IC50 values of 1.78 μM, 1.94 μM, and 3.07 μM. Its selective action and efficacy make it a valuable tool for studying tumor biology and evaluating potential therapeutic strategies targeting CAIX/CAXII in cancer research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2439165-37-2
Applications	CAIX/CAXII Inhibitor
Formula	C₂₄H₂₁IN₄O₄S₂
Molecular Weight	620.48
SMILES	IC1=CC=C(N=C2SCC(NC3=CC=CC=C3CC)=O)C(C(N2C4=CC=C(S(N)(=O)=O)C=C4)=O)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.