Fig. 1 · Structure
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Calcimycin
Cation Ionophore
Calcimycin is a divalent cation ionophore that effectively transports calcium and magnesium ions across cellular membranes. It is known to induce calcium-dependent cell death by elevating intracellular calcium levels, thereby triggering apoptotic and autophagic pathways. In addition to its role in promoting cell mortality, Calcimycin inhibits the growth of Gram-positive bacteria and certain fungi, along with suppressing ATPase activity and uncoupling oxidative phosphorylation in mammalian cells. This versatile compound is essential for research into calcium signaling, cell death mechanisms, and antibacterial activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 52665-69-7 |
| Applications | Cation Ionophore |
| Formula | C29H37N3O6 |
| Molecular Weight | 523.62 |
| Synonyms | A-23187; Antibiotic A-23187 |
| SMILES | O=C(C1=C2N=C(C[C@H]3O[C@]4(O[C@H]([C@H](C)C(C5=CC=CN5)=O)[C@H](C)C[C@H]4C)CC[C@H]3C)OC2=CC=C1NC)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.