Fig. 1 · Structure
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Calhex 231
CaSR Inhibitor
Calhex 231 is a potent negative allosteric modulator targeting the calcium-sensing receptor (CaSR), exhibiting an IC50 of 0.39 μM for inhibiting increases in [3H]inositol phosphates. This compound is instrumental in research applications related to traumatic hemorrhagic shock and diabetic cardiomyopathy, providing insights into the roles of CaSR in these pathophysiological conditions. Calhex 231 offers a valuable tool for investigating the modulation of CaSR signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor, Modulator |
| CAS Number | 652973-93-8 |
| Applications | CaSR Inhibitor |
| Formula | C25H27ClN2O |
| Molecular Weight | 406.95 |
| SMILES | O=C(N[C@@H]1[C@@H](N[C@@H](C2=C3C=CC=CC3=CC=C2)C)CCCC1)C4=CC=C(Cl)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.