Fig. 1 · Structure
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Calphostin C
PKC Inhibitor
Calphostin C is a selective inhibitor of protein kinase C (PKC), displaying an IC50 of 0.05 μM. This compound disrupts PKC-mediated phosphorylation, promoting tumor apoptosis and exhibiting potential therapeutic benefits. Additionally, Calphostin C has been shown to restore Na+/K+ ATPase activity in diabetic mouse sciatic nerves, offering insights into its role in mitigating diabetic complications. It serves as a valuable tool for research in cancer biology and neuropathy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 121263-19-2 |
| Applications | PKC Inhibitor |
| Formula | C44H38O14 |
| Molecular Weight | 790.76 |
| Synonyms | UCN-1028C |
| SMILES | O=C(O[C@@H](CC1=C(C(C2=C(C=C(C(C3=C4C5=C(O)C=C3OC)=C2C1=C4C(C[C@@H](C)OC(C6=CC=CC=C6)=O)=C(OC)C5=O)OC)O)=O)OC)C)OC7=CC=C(C=C7)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.