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CAM833

Catalog No.: A30139
BRCA2-RAD51 Interaction Inhibitor
CAM833 is a potent orthosteric inhibitor of the BRCA2-RAD51 interaction, exhibiting a Kd of 366 nM against ChimRAD51 protein. This compound also disrupts RAD51 oligomerization, leading to enhanced progression of G2/M-arrested cells into apoptosis. CAM833 is valuable for research applications aimed at studying DNA repair mechanisms and therapeutic strategies in BRCA2-related cancers.
CAM833 2758364-02-0 BRCA2-RAD51 Interaction Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$235.00
In stock
5mg
$330.00
In stock
10mg
$570.00
In stock
25mg
$1,160.00
In stock
50mg
$1,625.00
In stock
100mg
$2,865.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCAM833 is a potent orthosteric inhibitor of the BRCA2-RAD51 interaction, exhibiting a Kd of 366 nM against ChimRAD51 protein. This compound also disrupts RAD51 oligomerization, leading to enhanced progression of G2/M-arrested cells into apoptosis. CAM833 is valuable for research applications aimed at studying DNA repair mechanisms and therapeutic strategies in BRCA2-related cancers.
Product Information
Catalog NumA30139
FormulaC26H26ClFN4O5
Molecular Weight528.96
CAS Number2758364-02-0
SMILESC[C@@H](C1=C(C=C(C=C1)OC)Cl)NC([C@H]2N(C[C@@H](C2)O)C(CNC(C3=NC4=C(C=C(C=C4)F)C=C3)=O)=O)=O
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
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Cell Cycle > RAD51