PKI(5-22) amide is the active inhibitory fragment of the protein kinase A (PKA) inhibitor protein. It effectively blocks PKA activation by competitively inhibiting its catalytic subunit. However, PKI(5-22) amide does not prevent homologous desensitization of corticotropin-releasing factor 1 (CRF1) receptors, indicating a selective mechanism of action focused on PKA signaling.
PKI(5-22) amide is the active inhibitory fragment of the protein kinase A (PKA) inhibitor protein. It effectively blocks PKA activation by competitively inhibiting its catalytic subunit. However, PKI(5-22) amide does not prevent homologous desensitization of corticotropin-releasing factor 1 (CRF1) receptors, indicating a selective mechanism of action focused on PKA signaling.
Product Information
Catalog Num
A23904
Formula
C84H137N29O26
Molecular Weight
1969.2
CAS Number
100853-58-5
Synonyms
PKI(5-22)amide
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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