Fig. 1 · Structure
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cAMP Dependent PK Inhibitor (5-22) amide
PKI(5-22) amide is the active inhibitory fragment of the protein kinase A (PKA) inhibitor protein. It effectively blocks PKA activation by competitively inhibiting its catalytic subunit. However, PKI(5-22) amide does not prevent homologous desensitization of corticotropin-releasing factor 1 (CRF1) receptors, indicating a selective mechanism of action focused on PKA signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 100853-58-5 |
| Formula | C84H137N29O26 |
| Molecular Weight | 1969.2 |
| Synonyms | PKI(5-22)amide |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
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| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.