Fig. 1 · Structure
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CAN508
CDK9/cyclin T1 Inhibitor
CAN508 is a potent ATP-competitive inhibitor of the CDK9/cyclin T1 complex, displaying an IC50 of 0.35 μM. This compound demonstrates a remarkable 38-fold selectivity for CDK9/cyclin T over other cyclin-dependent kinases, making it a valuable tool for investigating transcriptional regulation. Its antitumor activity positions CAN508 as a relevant candidate for research into cancer therapeutics and related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 140651-18-9 |
| Applications | CDK9/cyclin T1 Inhibitor |
| Formula | C9H10N6O |
| Molecular Weight | 218.22 |
| SMILES | OC1=CC=C(/N=N/C2=C(N)NN=C2N)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.