CAN508 is a potent ATP-competitive inhibitor of the CDK9/cyclin T1 complex, displaying an IC50 of 0.35 μM. This compound demonstrates a remarkable 38-fold selectivity for CDK9/cyclin T over other cyclin-dependent kinases, making it a valuable tool for investigating transcriptional regulation. Its antitumor activity positions CAN508 as a relevant candidate for research into cancer therapeutics and related signaling pathways.
CAN508 is a potent ATP-competitive inhibitor of the CDK9/cyclin T1 complex, displaying an IC50 of 0.35 μM. This compound demonstrates a remarkable 38-fold selectivity for CDK9/cyclin T over other cyclin-dependent kinases, making it a valuable tool for investigating transcriptional regulation. Its antitumor activity positions CAN508 as a relevant candidate for research into cancer therapeutics and related signaling pathways.
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