Fig. 1 · Structure
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Candesartan methyl ester
Ang II Receptor Antagonist
Candesartan methyl ester is an antagonist of the angiotensin II (Ang II) receptor, exhibiting an IC50 of 66 nM. This compound demonstrates significant blood pressure-lowering activity in rat models, making it a valuable tool for research in cardiovascular pharmacology and hypertension studies. Its ability to modulate Ang II receptor activity offers potential insights into therapeutic strategies for hypertension and related cardiovascular disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 139481-69-9 |
| Applications | Ang II Receptor Antagonist |
| Formula | C25H22N6O3 |
| Molecular Weight | 454.48 |
| SMILES | CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.