Fig. 1 · Structure
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CAP-53194
Cat. No.
A56900
CAS
660817-08-3
Polo-like Kinase (PLK)
CAP-53194 is a selective inhibitor of Polo-like Kinase 1 (PLK1) with promising anticancer properties. It demonstrates significant selectivity, showing over 100-fold inhibition of PLK1 compared to PLK2-4 and other cell cycle-related kinases due to its ability to target unique features within the PLK1 binding site. CAP-53194 conforms to Lipinski's rule of five and meets various ADMET criteria, suggesting favorable pharmacokinetic characteristics. This compound represents a novel class of potential PLK1 inhibitors for further research and development in cancer therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 660817-08-3 |
| Applications | Polo-like Kinase (PLK) |
| Formula | C21H14N6O5 |
| Molecular Weight | 430.37 |
| SMILES | O=C(NC1=CC=C(C=C1)[N+]([O-])=O)C2=C(N(N=N2)C3=CC=C(C=C3)[N+]([O-])=O)C4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.