Fig. 1 · Structure
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Carbenoxolone
Gap Junction Blocker
Carbenoxolone is a selective inhibitor of Pannexin1 and a potent gap junction blocker. It modulates voltage-gated currents in both wild-type and mutant Panx1 channels, effectively inhibiting their activity in response to stimuli. Additionally, Carbenoxolone interacts with β-amyloid 42, preventing aggregation of peptides, fibrils, and oligomers, thereby offering potential neuroprotective and nootropic effects. This compound is utilized in research focused on Alzheimer's disease and the pathophysiology of liver fibrosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 5697-56-3 |
| Applications | Gap Junction Blocker |
| Formula | C34H50O7 |
| Molecular Weight | 570.76 |
| SMILES | CC(C)([C@]1([H])CC[C@@]([C@@]2(CC[C@]3(CC[C@](C(O)=O)(C[C@]3(C2=C4)[H])C)C)C)5C)[C@@H](OC(CCC(O)=O)=O)CC[C@]1(C)[C@@]5([H])C4=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.