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Carboxyatractyloside

Adenine Nucleotide Translocator Inhibitor

Carboxyatractyloside is a potent inhibitor of adenine nucleotide translocase, representing a significant toxic constituent of Xanthium sibiricum. By competing with ADP for binding, it effectively obstructs the translocation of ADP and ATP across the inner mitochondrial membrane, leading to the inhibition of ADP-stimulated respiration. Additionally, in conjunction with Cyclosporin A, Carboxyatractyloside promotes permeability transition in liver mitochondria, demonstrating pronounced hepatotoxic and nephrotoxic properties. This compound is extensively utilized in research contexts focused on hepatotoxicity, nephrotoxicity, and the pathophysiology of Alzheimer's disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	35988-42-2
Applications	Adenine Nucleotide Translocator Inhibitor
Formula	C₃₁H₄₆O₁₈S₂
Molecular Weight	770.82
Synonyms	CATR
SMILES	C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C(O)=O)(C[C@H](C2)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)OS(=O)(O)=O)OS(=O)(O)=O)OC(CC(C)C)=O)C(O)=O)C[C@@](C([C@@H]4O)=C)([H])CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.