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CARM1 degrader-2

CARM1 Degrader

CARM1 degrader-2 is a potent PROTAC that specifically targets co-activator associated arginine methyltransferase (CARM1) for degradation, exhibiting a DC50 of 8.8 nM. This compound facilitates the degradation of CARM1 through a VHL- and proteasome-dependent mechanism, leading to the inhibition of methylation of key substrates such as poly(A)-binding protein PABP1 and BAF155. Its ability to inhibit CARM1 function makes CARM1 degrader-2 a valuable tool in breast cancer research, particularly in studies focused on cancer cell migration.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3032785-06-8
Applications	CARM1 Degrader
Formula	C₇₂H₁₀₀N₁₂O₇S
Molecular Weight	1277.71
SMILES	O=C([C@H]1N(C([C@@H](NC(CN2CCN(CC3CCN(CC4CCN(C(CCC5=CC=C(OC6=CC=CC(C(N(C)CC7=CC(C8CCN(CCNC)CC8)=NC=C7)=O)=C6)C=C5)=O)CC4)CC3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C9=CC=C(C%10=C(C)N=CS%10)C=C9)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.