CARM1 degrader-2 is a potent PROTAC that specifically targets co-activator associated arginine methyltransferase (CARM1) for degradation, exhibiting a DC50 of 8.8 nM. This compound facilitates the degradation of CARM1 through a VHL- and proteasome-dependent mechanism, leading to the inhibition of methylation of key substrates such as poly(A)-binding protein PABP1 and BAF155. Its ability to inhibit CARM1 function makes CARM1 degrader-2 a valuable tool in breast cancer research, particularly in studies focused on cancer cell migration.
CARM1 degrader-2 is a potent PROTAC that specifically targets co-activator associated arginine methyltransferase (CARM1) for degradation, exhibiting a DC50 of 8.8 nM. This compound facilitates the degradation of CARM1 through a VHL- and proteasome-dependent mechanism, leading to the inhibition of methylation of key substrates such as poly(A)-binding protein PABP1 and BAF155. Its ability to inhibit CARM1 function makes CARM1 degrader-2 a valuable tool in breast cancer research, particularly in studies focused on cancer cell migration.
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