Fig. 1 · Structure
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CARM1-IN-4
CARM1 Inhibitor
CARM1-IN-4 is a potent inhibitor of CARM1, exhibiting an IC50 of 9 nM for CARM1 and 56 nM for PRMT1. This compound effectively inhibits the methyltransferase activity of CARM1, thereby preventing the methylation of downstream substrates. CARM1-IN-4 demonstrates significant anti-proliferative effects in colorectal cancer cell lines, promotes apoptosis, and exhibits notable antitumor activity, making it valuable for research in cancer therapeutics and epigenetic regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2878481-07-1 |
| Applications | CARM1 Inhibitor |
| Formula | C24H42N2O4 |
| Molecular Weight | 422.60 |
| SMILES | CN(C[C@@H](O)CNC)CC1=CC=CC=C1OC2CCC(COCC)(COCC)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.